q17-dataset-feasibility-finding

{
 "packet_id": "ip:q17-dataset-feasibility-finding",
 "schema_version": 2,
 "artifact_type": "argument_fabric_claim_packet",
 "source": {
  "source_id": "synthetic:q17-dataset-feasibility-finding",
  "title": "Empirical Feasibility Evaluation: Recovery Trajectory Hierarchy Wager Protocol Against Existing DOC Datasets",
  "author": "Hermes autonomous loop 009 (dataset feasibility investigation)",
  "external_sources": [
   {
    "source_id": "doi:10.1001/jamaneurol.2021.2043",
    "title": "Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study",
    "author": "McCrea MA, Giacino JT, Barber J, et al.",
    "url": "https://doi.org/10.1001/jamaneurol.2021.2043",
    "source_quality": "peer_reviewed_clinical"
   },
   {
    "source_id": "doi:10.1080/02699052.2019.1658220",
    "title": "Demographical and clinical indices for long-term evolution of patients in vegetative or in minimally conscious state",
    "author": "Porta et al.",
    "url": "https://doi.org/10.1080/02699052.2019.1658220",
    "source_quality": "peer_reviewed_clinical"
   },
   {
    "source_id": "doi:10.1093/braincomms/fcz017",
    "title": "Longitudinal assessments highlight long-term behavioural recovery in disorders of consciousness",
    "author": "Luppi et al.",
    "url": "https://doi.org/10.1093/braincomms/fcz017",
    "source_quality": "peer_reviewed_clinical"
   },
   {
    "source_id": "doi:10.1101/2025.03.02.25322248",
    "title": "Acute biomarkers of consciousness are associated with recovery after severe traumatic brain injury",
    "author": "Edlow BL et al.",
    "url": "https://doi.org/10.1101/2025.03.02.25322248",
    "source_quality": "preprint_clinical"
   },
   {
    "source_id": "doi:10.1007/s00134-023-07072-1",
    "title": "Acute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial",
    "author": "Wu et al.",
    "url": "https://doi.org/10.1007/s00134-023-07072-1",
    "source_quality": "peer_reviewed_rmct"
   }
  ],
  "tradition_scope": "empirical_feasibility"
 },
 "target_question_id": "q:brain-if-consciousness-fundamental",
 "extracted_by": "hermes_loop_009",
 "extracted_at": "2026-07-27",
 "status": "hermes_proposed",
 "claims": [
  {
   "claim_id": "cl:recovery-wager-no-single-dataset-meets-protocol",
   "source_type": "literature_survey",
   "source_id": "synthetic:q17-dataset-feasibility-finding",
   "source_span": {
    "locator": "Systematic PubMed search for DOC recovery longitudinal datasets with CRS-R subscale data (2018-2026)",
    "quote": "No existing single DOC recovery dataset simultaneously satisfies the wager protocol's minimum requirements: N ≥ 50 patients with ≥ 4 CRS-R assessments over ≥ 6 months with subscale data. The closest candidates (TRACK-TBI msTBI cohort, N=484, 4 timepoints, 12 months) lack CRS-R subscale data, using GOSE/DRS instead. The largest CRS-R DOC cohort identified (Porta et al., N=216) uses diagnostic categories rather than subscale trajectories. Published CRS-R trajectory studies (Luppi et al., N=39; Edlow et al., N=55) fall below the N≥50 threshold with sufficient longitudinal granularity."
   },
   "claim_text": "The recovery trajectory hierarchy wager protocol's minimum data requirements (N ≥ 50 patients with ≥ 4 CRS-R subscale assessments over ≥ 6 months) are not satisfied by any single existing publicly documented DOC recovery dataset. The three candidate datasets that most closely approach the requirements are: (1) TRACK-TBI msTBI cohort (N=484, 4 timepoints at 2wk/3mo/6mo/12mo, ~79 initial DOC patients) — meets N and longitudinal structure requirements but uses GOSE/DRS functional scales rather than CRS-R subscale data; (2) Porta et al. 2019 (N=216, follow-up at 12/24/36 months) — meets N but uses clinical VS/MCS/EMCS diagnostic classification rather than CRS-R subscale trajectory data; (3) individual CRS-R trajectory studies (Luppi et al. N=39, Edlow/Bodien e